Pluripotent stem cells derived from different cell types are equally susceptible to reprogramming, indicates a recent study by the University of Helsinki and the National Institute for Health and Welfare, Finland. However, the genotype of the donor strongly influences the differentiation of the stem cell.
Published in the Stem Cell Reports journal, the results of the study disprove the assumption that an “epigenetic memory” of cells from different tissue types would significantly impact the differentiation of induced pluripotent stem (iPS) cells.
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